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ea0037gp.26.04 | Thyroid – hypothyroidism | ECE2015

Nkx2.5 gene mutations are not associated with congenital heart defects in children with thyroid dysgenesis

Ramos Helton Estrela , de Oliveira Cerqueira Taise Lima , Ramos Yane Rocha , Leite Paula , Santos Jailciele , San Martin Daniel , Costa Anabel Goes , Fernandes Vladimir , Strappa Giorgia , de Jesus Mariana Souza , Amorim Tatiana , Ladeia Ana Marice

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...

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Endocrine Abstracts

Nkx2.5 gene mutations are not associated with congenital heart defects in children with thyroid dysgenesis

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